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Home » Products » Anti Cancer Drug » Erlotinib

Erlotinib

Erlotinib
Erlotinib
Product Code : 45612
Brand Name : Erlotinib
Product Description

Erlonat (Erlotinib hydrochloride) is a drug used to treat non-small cell lung cancer, pancreatic cancer and several other types of cancer. Erlonat (Erlotinib) is marketed in the United States by Genetech and OSI Pharmaceuticals and elsewhere by Roche.

Erlonat (Erlotinib) specifically targets theepidermal growth factor receptor (EGFR) tyrosine kinase, which is highly expressed and occasionallymutated in various forms of cancer. Erlonat (Erlotinib) binds in a reversible fashion to the triphosphate(ATP) binding site of the receptor For the signal to be transmitted, two members of the EGFR family need to come together to form a homodimer. These then use the molecule of ATP to autophosphorylate each other, which causes a conformational changein their intracellular structure, exposing a further binding site for binding proteins that cause a signal cascade to the nucleus. By inhibiting the ATP, autophosphorylation is not possible and the signal is stopped.

Erlonat (Erlotinib) has shown a survival benefit in the treatment of lung cancer in phase III trials. Erlonat (Erlotinib) has been approved for the treatment of locally advanced or metastatic non-small cell lung cancer that has failed at least one prior chemotherapy regimen. In November 2005, the U.S. Food and Drug Administration (FDA) approved the use of Erlonat (Erlotinib)in combination with for treatment of locally advanced, unresectable, or metastaticpancreatic cancer .

Brand Name:

Erlonat

Generic Name:

Erlotinib

Company:

Natco

Strength:

150mg

Packing:

1x30

Type:

Capsule

Uses:

Anticancer




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